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A hybrid calcium salt of citric and malic acids, with high bioavailability and pH stability. Widely used in fortified foods (juices, cereals) and supplements, it enhances calcium absorption—especially in acidic conditions—supporting bone and dental health
| Calcium Citrate Malate |  |
| CAS | 142606-53-9 |
| molecular weight | 670.583 |
| molecular formula | C16H14Ca4O19 |
| solubility | Slightly soluble in water, more soluble than calcium citrate and calcium malate, can stably dissolve under acidic conditions |
| color | White |
| flavor | Odorless |
| state | Crystalline granules or powder |
| melting point | 185℃ |
| boiling point | 309.6ºC |
Calcium citrate malate (CCM), a compound combining calcium with citric and malic acids, offers distinct advantages that make it a preferred form of calcium supplementation for optimal health. Here’s a breakdown of its key benefits:
1. Exceptional Bioavailability & Efficient Absorption
Enhanced Solubility: The combination of citric and malic acids forms a stable, water-soluble complex that keeps calcium in a dissolvable state, even in low-acid environments (like the intestines of older adults or those taking acid-suppressing medications). This increases calcium uptake by up to 30% compared to calcium carbonate, ensuring more nutrient reaches bones and cells.
No Stomach Acid Dependency: Unlike calcium carbonate, which requires strong stomach acid to break down, CCM is absorbed efficiently throughout the digestive tract—ideal for individuals with sensitive digestion, low stomach acid, or gastrointestinal conditions.
2. Gentle on the Digestive System
Reduced Constipation Risk: Traditional calcium supplements (e.g., calcium oxide) often cause constipation due to their binding effects in the gut. CCM’s organic acid structure minimizes this issue, promoting smoother digestion and better tolerance, even at higher doses.
Balanced Osmotic Activity: The citric and malic acids buffer calcium’s potential to draw water into the intestines, reducing the risk of diarrhea or cramping—making it suitable for long-term use without digestive discomfort.
3. Supports Bone Health & Mineral Balance
Optimal Bone Mineralization: CCM delivers bioavailable calcium directly to bones, where it’s essential for maintaining density, strength, and structural integrity. Malic acid, a key component of the Krebs cycle, also supports energy production in osteoblasts (bone-building cells), enhancing calcium utilization for bone formation.
Synergy with Other Nutrients: Citric acid improves the absorption of non-heme iron (from plant sources) and zinc, making CCM a strategic choice for multi-nutrient supplements—especially for individuals at risk of mineral deficiencies (e.g., vegetarians, pregnant women).
4. Antioxidant & Inflammatory Support
Dual Acid Protection: Citric and malic acids act as antioxidants, neutralizing free radicals and reducing oxidative stress in cells. This protects bone tissue from inflammatory damage and supports overall immune health, potentially lowering the risk of age-related bone loss (osteoporosis) or inflammatory conditions.
pH Regulation: By maintaining a balanced pH in bodily fluids, CCM helps prevent calcium from depositing in soft tissues (e.g., arteries or kidneys), reducing the risk of calcification while ensuring calcium is directed to where it’s needed most—bones and teeth.
5. Versatile Application in Fortified Foods
Food Fortification Friendly: CCM’s stability, mild taste, and solubility make it ideal for enriching beverages (e.g., juices, plant-based milks), cereals, and snacks. It fortifies foods without altering flavor or texture, making it a popular choice for enhancing calcium intake in mainstream diets, especially for children or picky eaters.
Calcium citrate malate stands out for its unique blend of high absorbability, digestive gentleness, and nutrient synergy, offering targeted support for bone health, mineral balance, and overall wellness. It’s an excellent choice for individuals seeking an effective, well-tolerated calcium supplement—particularly those with digestive sensitivities, nutrient absorption challenges, or a need for balanced multi-mineral support.
CCM’s unique molecular structure—chelated with citric and malic acids—ensures exceptional solubility and bioavailability, even in low-acid environments like the intestines of older adults or individuals with reduced stomach acid (common with age or medication use). This means:
Efficient Uptake Without Acid Dependency: Unlike calcium carbonate, which requires strong stomach acid to dissolve, CCM is absorbed efficiently throughout the small intestine, delivering more calcium to osteoblasts (bone-building cells) and reducing urinary calcium loss.
Ideal for Vulnerable Groups: Perfect for formulations targeting postmenopausal women (at risk of osteoporosis), older adults, or those with gastrointestinal conditions, as it maximizes calcium utilization where absorption is often compromised.
Synergistic Support for Osteoblasts: Malic acid, a key component of CCM, is integral to the Krebs cycle, providing energy for osteoblasts to synthesize collagen and deposit calcium into bone matrix. This boosts bone formation while citric acid stabilizes calcium ions, ensuring they’re available for mineralization rather than accumulating in soft tissues.
Reduced Bone Resorption Risk: By maintaining optimal calcium levels in the bloodstream, CCM helps blunt the release of parathyroid hormone (PTH), which can trigger bone breakdown. This dual action—promoting bone building while inhibiting excessive breakdown—supports long-term bone density and strength.
Digestive Tolerance for Sustained Use: CCM’s organic acid complex minimizes the constipation and bloating often associated with calcium supplements, making it suitable for daily use in formulations without compromising patient compliance. Its low osmotic effect ensures smooth gastrointestinal transit, even at higher doses.
Enhanced Multi-Nutrient Compatibility: Citric acid in CCM improves the absorption of other bone-supporting nutrients like magnesium, zinc, and non-heme iron, while malic acid pairs well with vitamin D (which enhances calcium uptake). This makes it a foundational ingredient in comprehensive bone health blends, addressing multiple nutrient gaps in a single formula.
Antioxidant Protection for Bone Tissues: The combined antioxidant activity of citric and malic acids reduces oxidative stress in osteocytes (bone cells), protecting against inflammation-induced bone loss and supporting the resilience of bone microarchitecture—critical for combating age-related fragility.
CCM’s neutral taste, water solubility, and chemical stability make it ideal for diverse delivery systems:
Fortified Foods & Beverages: Easily incorporated into calcium-fortified juices, plant-based milks, or nutrition bars without altering taste or texture, making bone health support accessible through everyday products (especially for children or those averse to pills).
Pharma-Grade Supplements: In tablets or capsules, it ensures consistent calcium release and bioavailability, even when combined with other ingredients, without the need for acidifying agents that can irritate the stomach.
By prioritizing absorbability, osteoblast function, and formulation flexibility, calcium citrate malate sets a gold standard for bone health products. It bridges the gap between efficacy and tolerability, making it the preferred choice for formulations designed to build, maintain, and protect bone mass across all life stages—especially where digestive health or nutrient absorption is a concern.
