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A chelated calcium-glycine compound, with high bioavailability and low gastrointestinal irritation. It supports bone density, muscle function, and nerve signaling, ideal for gentle calcium supplementation in seniors or those with digestive sensitivities.
| Calcium Glycinate |  |
| CAS | 35947-07-0 |
| molecular weight | 117.16 |
| molecular formula | C2H7CaNO2 |
| solubility | Soluble in water, insoluble in ethanol |
| color | White |
| flavor | Slightly sweet |
| state | Crystalline powder |
| melting point | 290ºC |
| boiling point | 240.9ºC |
Calcium glycinate, a chelated compound formed by binding calcium with the amino acid glycine, offers a unique set of benefits that combine the mineral’s essential roles with the metabolic advantages of glycine. Here’s a breakdown of its key benefits:
1. Exceptional Bioavailability & Efficient Absorption
Chelated Structure for Optimal Uptake: The bond between calcium and glycine creates a stable, low-molecular-weight complex that bypasses typical digestive barriers. This form of calcium is absorbed as a whole unit in the intestines, avoiding interactions with dietary fibers, oxalates, or other minerals (e.g., iron, zinc), resulting in higher bioavailability compared to non-chelated calcium salts (e.g., calcium carbonate, citrate).
Reduced Acid Dependency: Unlike calcium carbonate, which requires strong stomach acid to dissolve, calcium glycinate is absorbed efficiently across a wide pH range—ideal for individuals with low gastric acid (common in older adults, those on acid blockers, or with digestive disorders)—ensuring consistent calcium delivery to bones and cells.
2. Gentle on the Digestive System
Minimal Gastrointestinal Side Effects: The amino acid glycine buffers calcium’s potential to cause osmotic pressure in the intestines, reducing the risk of constipation, diarrhea, or stomach irritation—common issues with calcium oxide or sulfate. This makes it a well-tolerated option for long-term use, even for those with sensitive digestive systems or irritable bowel syndrome (IBS).
Stable and Non-Reactive: Maintains integrity through digestion without forming insoluble compounds, ensuring predictable release of calcium without adverse interactions in the gut.
3. Targeted Support for Bone & Muscle Health
Enhanced Bone Mineralization: Delivers bioavailable calcium to osteoblasts (bone-building cells), promoting the synthesis of hydroxyapatite (the mineral matrix of bones and teeth). This supports bone density, strength, and resilience, reducing the risk of osteoporosis and fractures, especially in postmenopausal women or older adults.
Muscle Function Optimization: Glycine aids in regulating electrolyte balance and calcium-mediated muscle contractions, reducing the risk of cramps, stiffness, or weakness. It also supports the synthesis of creatine (a key energy molecule for muscles), enhancing athletic performance and recovery.
4. Neuroprotective & Stress-Relieving Benefits
Nervous System Support: Glycine acts as an inhibitory neurotransmitter in the brain, promoting relaxation, improving sleep quality, and reducing anxiety. Combined with calcium’s role in nerve signal transmission, this makes calcium glycinate beneficial for individuals with stress-related disorders or neurological challenges (e.g., muscle tension, restless leg syndrome).
Blood-Brain Barrier Permeability: The glycine chelate helps calcium cross into the brain more effectively, supporting calcium-dependent processes in neurons, such as synaptic plasticity and neuroprotection—critical for cognitive function and memory.
5. Synergistic Nutrient Interaction
Amino Acid Metabolism Support: Glycine is a precursor to glutathione (the body’s master antioxidant) and creatine, enhancing cellular detoxification and energy production. This synergy with calcium creates a dual-action supplement that supports both skeletal health and overall metabolic wellness.
Safe for Multinutrient Formulas: Does not interfere with the absorption of other minerals or vitamins, making it ideal for inclusion in multi-vitamin blends, prenatal supplements, or senior formulas—especially for individuals who need comprehensive nutrient support without competitive interactions.
6. Versatile Application Across Life Stages
Pediatric to Geriatric Use: Safe for children (supporting bone growth and development), pregnant women (meeting increased calcium demands), and older adults (combating age-related bone loss and muscle wasting).
Sports Nutrition: Popular among athletes for its role in muscle contraction, recovery, and electrolyte balance, often paired with magnesium glycinate for enhanced neuromuscular support.
7. Regulatory Safety & Purity
Well-Tolerated and Research-Backed: Clinical studies confirm its high absorption and safety profile, with no reported toxicity even at high doses (under medical guidance). It is often preferred in clinical settings for patients with absorption disorders or chronic conditions.
Calcium glycinate stands out as a premium calcium supplement due to its superior bioavailability, digestive gentleness, and multifunctional benefits for bones, muscles, and the nervous system. It’s an excellent choice for individuals who prioritize nutrient efficiency, gastrointestinal comfort, or holistic wellness—especially those who have struggled with traditional calcium supplements or seek a calcium form that supports both physical and neurological health.
Calcium glycinate’s molecular structure—where calcium is bound to glycine, a naturally occurring amino acid—creates a stable, low-molecular-weight complex that bypasses common digestive barriers. Unlike non-chelated calcium salts (e.g., calcium carbonate, sulfate), which can react with dietary fibers, oxalates, or stomach acid to form insoluble compounds, this chelated form is absorbed as a complete unit in the intestines. This results in:
Higher Calcium Uptake: Studies show glycinate-bound calcium is absorbed up to 20–30% more efficiently than traditional calcium forms, ensuring more mineral reaches bones, muscles, and cells where it’s needed most.
pH-Independent Absorption: Stable across all digestive pH levels, it doesn’t rely on strong stomach acid to dissolve, making it ideal for older adults, those taking acid-suppressing medications, or anyone with low gastric acid—ensuring consistent nutrient delivery regardless of digestive health.
One of calcium glycinate’s defining advantages is its digestive tolerance, a critical factor for long-term compliance:
Minimal Gastrointestinal Side Effects: The glycine molecule buffers calcium’s potential to cause osmotic pressure in the intestines, reducing the likelihood of constipation, diarrhea, or stomach irritation—common complaints with calcium carbonate or oxide. This makes it suitable for individuals with sensitive digestive systems, irritable bowel syndrome (IBS), or anyone who has struggled with harsh calcium supplements.
Non-Reactive and Stable: Maintains its structure through digestion, avoiding the formation of gas-producing or irritating byproducts, so it can be taken with or without food without discomfort.
Beyond superior calcium delivery, calcium glycinate leverages glycine’s unique properties for holistic support:
Targeted Bone & Muscle Support: Delivers bioavailable calcium to osteoblasts (bone-building cells) to strengthen bone density and teeth, while glycine aids in muscle contraction regulation and electrolyte balance, reducing cramps and promoting recovery—ideal for athletes or older adults at risk of sarcopenia.
Neuroprotective and Stress-Relieving: Glycine acts as an inhibitory neurotransmitter in the brain, promoting relaxation, improving sleep quality, and reducing anxiety. Combined with calcium’s role in nerve signal transmission, this makes it a dual-action supplement for mental and physical well-being, particularly beneficial for those with stress-related muscle tension or neurological discomfort.
Synergy with Cellular Processes: Glycine is a precursor to glutathione (the body’s master antioxidant) and collagen, enhancing cellular detoxification, tissue repair, and skin health—turning a calcium supplement into a multi-nutrient ally for overall wellness.
Calcium glycinate’s safety and efficacy make it a universal choice:
Suitable for Diverse Needs: From pediatric formulas (supporting growing bones and gentle digestion in children) to prenatal supplements (meeting increased calcium demands during pregnancy) and senior care (combating age-related bone loss and digestive changes), it adapts to every life stage.
Drug and Nutrient Friendly: Does not interfere with the absorption of other minerals (e.g., iron, zinc) or medications, making it safe for inclusion in multi-vitamin blends or as a standalone supplement—no need to stagger doses or worry about competitive interactions.
Why Choose Calcium Glycinate?
It’s the go-to for anyone seeking a calcium supplement that works with the body, not against it—offering efficient absorption, digestive comfort, and added benefits from glycine’s metabolic support. Whether you’re managing sensitive digestion, prioritizing bone health, or seeking a supplement that enhances both physical and mental wellness, calcium glycinate delivers results without compromise.
Backed by science and designed for tolerance, it’s more than a calcium supplement; it’s a gentle, holistic solution for sustained health.
