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A calcium salt of L-threonic acid, analogous to its magnesium counterpart but for calcium delivery. It may enhance calcium absorption and bone mineralization, explored in specialized supplements for skeletal health.
| Calcium L-threonate |  |
| CAS | 70753-61-6 |
| molecular weight | 310.27 |
| molecular formula | C8H14CaO10 |
| solubility | Soluble in DMSO (slightly), water (slightly, heated) |
| color | Light brown |
| flavor | Odorless |
| state | Powder |
| melting point | >300℃ |
| boiling point | 518.9℃ |
Calcium L-threonate, a unique calcium compound formed by chelating calcium with L-threonic acid (a derivative of vitamin C), offers distinct advantages that set it apart as a versatile calcium supplement. Here’s a breakdown of its key benefits:
1. Exceptional Bioavailability & Brain-Permeable Calcium Delivery
Enhanced Absorption: The L-threonic acid molecule stabilizes calcium ions, protecting them from binding with other minerals (like iron or zinc) in the gut, resulting in higher bioavailability compared to traditional calcium salts (e.g., carbonate, citrate). This ensures more calcium is absorbed and transported to cells, including those in the brain.
Blood-Brain Barrier Penetration: Uniquely among calcium supplements, L-threonate helps calcium cross the blood-brain barrier, delivering the mineral directly to neurons. This supports calcium-dependent processes in the brain, such as neurotransmitter regulation, synaptic plasticity, and neuroprotection—critical for cognitive function and memory.
2. Dual Support for Bone Health & Cognitive Function
Optimal Bone Mineralization: Provides bioavailable calcium for bone density and strength, acting as a foundational nutrient for osteoblasts (bone-building cells). Unlike some calcium forms that may deposit in soft tissues, L-threonate directs calcium to skeletal tissues, reducing the risk of arterial calcification.
Cognitive Enhancement: Studies suggest L-threonate may improve memory and learning by enhancing synaptic connections and reducing age-related cognitive decline. It supports the production of brain-derived neurotrophic factor (BDNF), a protein vital for neuron growth and survival, making it a popular choice for supplements targeting brain health alongside bone support.
3. Antioxidant & Anti-Inflammatory Properties
Synergistic Vitamin C Derivative Benefits: L-threonic acid is a metabolite of vitamin C, inheriting its antioxidant potential to neutralize free radicals and reduce oxidative stress in cells. This protects both bone tissue and neurons from damage, supporting overall cellular health.
Inflammation Modulation: By regulating calcium-dependent signaling pathways, calcium L-threonate may dampen pro-inflammatory responses (e.g., reducing NF-κB activation), contributing to joint comfort and immune balance—especially beneficial for individuals with inflammatory conditions or age-related tissue degeneration.
4. Gentle on the Digestive System
Low Risk of Gastrointestinal Side Effects: The chelated structure minimizes the osmotic effect in the intestines, reducing the likelihood of diarrhea, constipation, or stomach discomfort commonly associated with calcium carbonate or sulfate. This makes it suitable for individuals with sensitive digestion, IBS, or those taking acid-suppressing medications.
Stable in Low-Acid Environments: Unlike calcium carbonate, which requires high stomach acid to dissolve, L-threonate remains soluble across a wide pH range, ensuring consistent absorption even in individuals with reduced gastric acid (e.g., older adults, post-menopausal women).
5. Supports Muscle Function & Cellular Signaling
Calcium Homeostasis: Maintains proper calcium balance in cells, critical for muscle contraction/relaxation, nerve impulse transmission, and heart rhythm regulation. This is particularly important for athletes, older adults, or anyone seeking to prevent muscle cramps or weakness.
Mitochondrial Energy Support: L-threonic acid aids in cellular energy production by supporting mitochondrial function, ensuring cells (including muscle and nerve cells) have adequate ATP to sustain activity and repair.
6. Versatile Formulation for Targeted Needs
Ideal for Multifunctional Supplements: Often combined with vitamin D, magnesium, or omega-3s in formulas designed to support bone-brain-muscle health simultaneously, appealing to consumers seeking holistic wellness.
Suitable for All Life Stages: From pediatric formulations (supporting growing bones and brain development) to senior supplements (combating osteoporosis and age-related cognitive decline), its safety and efficacy make it a flexible choice.
Calcium L-threonate stands out for its unique ability to deliver calcium to both skeletal tissues and the brain, while offering digestive gentleness and antioxidant benefits. It’s a strategic choice for individuals prioritizing cognitive health alongside bone support, or those who need a well-tolerated, high-absorption calcium supplement—especially useful for older adults, athletes, or anyone with digestive sensitivities.
Calcium L-threonate’s molecular structure protects calcium from binding with other substances in the digestive tract, ensuring significantly higher absorption rates compared to traditional calcium salts like calcium carbonate. This enhanced bioavailability means more calcium reaches the bones, where it’s crucial for bone mineralization and density. Unlike some calcium forms that rely on strong stomach acid to dissolve, calcium L-threonate remains stable across different pH levels, making it ideal for individuals with reduced gastric acid production, such as the elderly or those taking acid-suppressing medications.
This form of calcium actively promotes bone health in two key ways. First, it stimulates the activity of osteoblasts, the cells responsible for building new bone tissue. By providing readily available calcium and supporting osteoblast metabolism, calcium L-threonate helps strengthen bone structure. Second, it helps regulate osteoclasts, the cells that break down bone. By maintaining a balanced interplay between bone formation and resorption, it safeguards against excessive bone loss, reducing the risk of osteoporosis and fractures, especially in vulnerable populations like postmenopausal women.
Calcium L-threonate’s chelated nature minimizes its impact on the digestive tract, reducing the likelihood of common side effects like constipation or diarrhea that are often associated with other calcium supplements. This makes it a comfortable, long-term option for daily use. Additionally, as a derivative of vitamin C, L-threonic acid brings antioxidant properties to the compound, protecting bone cells from oxidative stress and inflammation. This extra layer of defense contributes to overall bone resilience and longevity, making calcium L-threonate not just a calcium source, but a comprehensive bone health solution.
