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Calcium butyrate is a calcium salt of short-chain fatty acids made by neutralizing butyric acid with calcium. It can simultaneously provide calcium ions and the gut-friendly metabolite butyrate, and is often used in calcium supplements for gut health and in feed additive development.
| Calcium Butyrate |  |
| CAS | 5743-36-2 |
| molecular weight | 214.27 |
| molecular formula | C8H14CaO4 |
| Water solubility at 25℃ | Water: Water: Slightly soluble in cold water, significantly more soluble in hot water. Slightly soluble in methanol; almost insoluble in ethanol, oils, acetone, and ether. |
| color | White / off-white crystalline powder |
| state | Has a slight sour, rancid smell characteristic of butyric acid (common to all butyrates), without the bitter taste of calcium salts |
1. Colon repair and fixing leaky gut
Butyrate is the only preferred energy source for colon epithelial cells, promoting villi growth, upregulating tight junction proteins (occludin, claudin), reducing gut permeability, and improving leaky gut. It inhibits the NF-κB inflammation pathway, downregulates pro-inflammatory factors TNF-α and IL-6, and helps with IBS, chronic colitis, and recurring bloating and diarrhea. It also regulates gut microbiota, enriching butyrate-producing beneficial bacteria while suppressing harmful bacteria, helping with constipation and irregular bowel movements.
2. Gentle, slow-release calcium with excellent digestive tolerance
It releases calcium steadily, keeping free calcium concentration in the gut mild, so calcium supplements are less likely to cause bloating or constipation. It also supports bone mineralization and maintains bone density, making it suitable for long-term use for people with sensitive stomachs.
3. Low-grade systemic anti-inflammation and metabolism support
Butyrate is an HDAC inhibitor, which reduces chronic low-grade inflammation in the body, improves insulin resistance, and helps regulate blood sugar and blood lipids, supporting metabolic syndrome management.
4. Gut-brain axis regulation
A small amount of butyrate can cross the blood-brain barrier, suppress brain microglial inflammation, boost BDNF (brain-derived neurotrophic factor), and relieve anxiety, mental fatigue, and mood disorders. Calcium helps stabilize nerve excitability at the same time, creating a combined gut-protecting and calming formula.
5. Cardiovascular support
It dilates vascular smooth muscles, stabilizes vascular tension, reduces chronic vascular inflammation and lipid peroxidation damage, and protects the integrity of blood vessel endothelium.
1. Feed additives
2. Overseas dietary supplements
3. Pharmaceutical intermediates
4. Raw materials for scientific research experiments
5. Pre-research materials for special medical foods
