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Magnesium butyrate is an organic magnesium salt of the short-chain fatty acid formed by neutralizing butyric acid with magnesium. It can provide both magnesium and the gut-friendly butyrate, and is often used in developing nutrition ingredients and feed additives for gut health.
Magnesium Dibutyrate |  |
| CAS | 556-45-6 |
| molecular weight | 198.50 g/mol |
| molecular formula | C8H14MgO4 |
| Appearance | White |
| Form | White to off-white fluffy crystalline powder |
| solubility（25℃） | Water: Slightly soluble in cold water, solubility increases slightly in hot water. Slightly soluble in methanol; almost insoluble in ethanol, fats, acetone, and ether. |
| Smell/taste | Has a slight sour, rancid smell characteristic of butyric acid (common to butyrates), without the usual bitterness of magnesium salts |
1. Gut Barrier Repair
Butyrate is the preferred energy source for colon epithelial cells, promoting intestinal villi growth, upregulating tight junction proteins, repairing leaky gut, and reducing intestinal permeability. It inhibits the NF-κB inflammatory pathway, downregulates pro-inflammatory factors TNF-α and IL-6, and helps ease irritable bowel syndrome (IBS), chronic colitis, and recurring bloating and diarrhea. It also regulates gut microbiota, enriches beneficial butyrate-producing bacteria, inhibits harmful bacteria growth, and improves constipation and irregular bowel movements.
2. Gentle, Slow-Release Magnesium with Excellent Digestive Tolerance
Maintains steady free magnesium levels in the gut, large doses are less likely to cause bloating or diarrhea, and it's suitable for long-term use in people with sensitive stomachs. Participates in the metabolism of over 300 enzymes, helps with nighttime leg cramps, muscle tightness, post-exercise soreness; soothes overactive nerves and aids in improving mild sleep disturbances.
3. Low-Level Systemic Anti-Inflammation and Metabolic Regulation
Butyrate is an HDAC (histone deacetylase) inhibitor, reducing chronic systemic inflammation, improving insulin resistance, and supporting blood sugar and lipid regulation, making it useful for managing metabolic syndrome.
4. Gut-Brain Axis Bidirectional Regulation
A small amount of butyrate crosses the blood-brain barrier, inhibiting microglial inflammation in the brain and increasing BDNF (brain-derived neurotrophic factor), helping relieve anxiety, mental fatigue, and emotional imbalances. Magnesium simultaneously stabilizes central nervous system excitability, creating a unique gut-friendly, calming formula.
5. Cardiovascular Support
Relaxes vascular smooth muscles and helps maintain stable blood pressure, reduces chronic vascular inflammation and lipid peroxidation, and protects vascular endothelial health.
1. Overseas dietary supplements
2. Feed additives
3. Pharmaceutical intermediates
4. Raw materials for scientific research experiments
5. Pre-research raw materials for special medical foods
